PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by Brian FengEpithelial-mesenchymal transition has long been studied as a physiologic process that is critical for embryonic development, wound healing, and cancer progression. Activation of the EMT program confers on cancer cells many cellular traits associated with high-grade malignancies. These include invasion, motility, the acquisition of stem cell-like […]
- by Margaret A ElpersMacrophages are innate immune cells contributing to tissue homeostasis and various pathologies. Signals from their environment can lead macrophages to adapt distinct functional phenotypes, a process called polarization. Because macrophages have been previously shown to degrade the nuclear envelope proteins lamin A/C upon pro-inflammatory polarization, and […]
- by Kevin A SwiftNecrotizing enterocolitis (NEC) is the most deadly gastrointestinal disease in preterm neonates, with up to 50% mortality. There is no cure for NEC. Enhancing our understanding of intestinal epithelial cell (IEC) responses to NEC will provide novel therapeutic targets. The RNA-binding protein insulin-like growth factor 2 […]
- by Jennifer J UehlingFor generalist animals that have a broad range of food choices, the specific diet characteristics that are important for health and fitness are often unclear. Here, we examine whether individual variation in diet composition predicts nestling mass and fledge success, and we identify potential drivers of […]
- by Tegan S HoranMeiotic recombination generates crossovers (COs), reciprocal exchanges between homologous chromosomes critical for accurate chromosome segregation. Inappropriate CO frequency and distribution drive aneuploidy in human oocytes, with error rates up to 10-fold higher than in sperm despite females exhibiting higher CO frequencies. COs form in the context […]
- by Tejas SubramanianCONCLUSION: Wound complications after DAA THA are relatively uncommon and often manageable with conservative measures. Obesity, female sex, and longitudinal incisions are associated with higher complication risk. Surgical technique, including consideration of incision type and appropriate postoperative wound management, may help minimize complications.
- by Chengchao DingSchlafens proteins (SLFNs) are interferon-inducible regulators of RNA metabolism that influence antiviral defense and cell fate. Human SLFN14 is a ribosome-associated endoribonuclease whose pathogenic variants cause autosomal dominant inherited thrombocytopenia (IT), but the molecular basis of this disorder remains unclear. Here, using HEK293T cells expressing human […]
- by Yaqing ZhangA hallmark of pancreatic cancer is an extensive fibroinflammatory stroma. Myeloid cells, including abundant macrophages, are a prevalent cellular component of the pancreatic cancer microenvironment and a key driver of immunosuppression. Identifying mechanisms of myeloid-cell driven immunosuppression is thus key to developing therapeutic approaches. Harnessing single-cell […]
- by Ellen W van WijngaardenToxic metals, including cobalt, are often the cause of the contamination of rivers and lakes in mining regions. Heavy metal water pollution has been linked to numerous human health problems, prompting the need for environmental remediation. Existing techniques for removing heavy metals from water, such as […]
- by Tracy StokolCONCLUSIONS: NOD scid γ mice can be engrafted with canine immune cells.
- by Leanne R DonahueUltraviolet-B irradiation (UVB) induces an epidermal damage response including keratinocyte hyperplasia, immune cell infiltration, and the recruitment of follicular melanocyte stem cells to the interfollicular epidermis. Here, we establish the oncofetal chromatin remodeling factor High mobility group AT-hook 2 (Hmga2) as a regulator of these phenotypes […]
- by Leo A PieplesCONCLUSIONS AND CLINICAL IMPORTANCE: This report represents only the second clinical description of FXIII deficiency in dogs and the first genetic characterization of this disorder in companion animals. The identified F13A1 variant provides a molecular diagnosis and enables genetic testing for this bleeding disorder in Black […]
- by Eric R ZhaoCONCLUSION: After ACDF, pain improvements typically plateau within 6 weeks, while functionality can continue to improve through 6 months. Patients with myelopathy tend to experience later improvement plateaus compared with patients with radiculopathy-only. These findings may improve diagnosis-dependent patient education and postoperative counseling.
- by Jiafei ZhanCONCLUSION: Substantial evidence is presented demonstrating that the pathogenicity of SS2 can be effectively attenuated by curcumin via inhibition of the hemolytic activity of SLY, which supports the potential utility of curcumin as a host-directed anti-virulence agent for SS2 infections.
- by Mustafa KayaMetastasis is facilitated by epithelial-to-mesenchymal transition (EMT), a process in which epithelial cancer cells, including breast cancer cells, acquire mesenchymal-like phenotypes. Production of reactive oxygen species (ROS) by NADPH oxidase 2 (NOX2) is a principal inflammatory and antimicrobial feature of myeloid cells. Inflammation has been linked […]
- by Breanna Cole-Skinner[This corrects the article DOI: 10.3389/fcell.2024.1348707.].
- by Jacob OdellLamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery. However, how individual lamin isoforms regulate LBR localization and anchorage remains unclear. Using mouse embryonic fibroblasts lacking all endogenous lamins, we […]
- by Ayesh AwadCrohn's disease is biologically heterogeneous, and current clinical classifications poorly predict treatment response or disease progression. The molecular programs that drive clinical outcomes in Crohn's disease remain poorly defined. We generated and analyzed whole-transcriptome RNA-sequencing data from non-inflamed colonic biopsies of 101 well-characterized Crohn's disease patients. […]
- by Yanlin ZiThe ability to adapt to nutrient stress, such as amino acid limitation, is crucial for cell survival. The mTORC1 complex and integrated stress response (ISR) are two mechanisms that sense the availability of amino acids and regulate protein synthesis. Here, we reveal a new SIRT2-mediated pathway, […]
- by Surya P BhattCONCLUSIONS AND RELEVANCE: In this cohort study, COPD was associated with lower life expectancy, including in adults who never smoked.