This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.

• Argonaute proteins orchestrate Meiotic Sex Chromosome Inactivation and timing of the spermatogenic transcriptional program
  June 29, 2026 by Maria de Las Mercedes Carro
  Argonaute proteins (AGO) are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we demonstrate that AGO3 and AGO4, but not AGO2, localize to the sex chromatin of pachytene spermatocytes, where they are required for the transcriptional silencing of XY-linked genes that characterizes Meiotic […]
• Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models
  June 26, 2026 by Parwiz Abrahimi
  Intravesical therapies are the mainstay of bladder cancer (BCa) management, but their efficacy is limited by toxicities and recurrences. While CAR T cell therapy has shown promise in hematologic malignancies, its application in solid tumors is limited by poor trafficking and on-target off-tumor toxicities. Here, we […]
• Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains
  June 26, 2026 by Susanna Zheng
  INTRODUCTION: Early-life social experiences have a profound impact on the development of the brain and behavior. Previous work has shown that prairie voles (Microtus ochrogaster) raised in a socially limited environment (raised by a single mother and isolated after weaning) engaged in more social behaviors compared […]
• Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity
  June 26, 2026 by Shiying Huang
  Proper functions of cellular organelles require tight control of membrane phospholipid composition, yet the mechanisms by which lipid imbalances are sensed and corrected remain largely unknown. Here, we present evidence of an unexpected metabolic connection between plasma membrane (PM) phosphoinositide metabolism and two key anionic lipids, […]
• Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation
  June 25, 2026 by Honghai Liu
  Heart muscle growth and regeneration require the proliferation of cardiomyocytes. Rapid pulsatile increases in cytosolic Ca2+ concentration, called calcium transients (CaTs), trigger cardiomyocyte contractions, but how cardiomyocytes adapt Ca2+ signaling during proliferation is largely unknown. Here, we show that cardiomyocyte proliferation requires changes in Ca2+ signaling. […]
• Neuron-specific enolase enzymatic activity as a biomarker to discriminate neurologic and orthopedic gait abnormalities in dogs
  June 24, 2026 by Amy Huynh
  CONCLUSIONS AND CLINICAL IMPORTANCE: Our results suggest that NSE-a is superior to NSE-p for differentiating neurologic from musculoskeletal gait abnormalities. Future research should explore its potential as a point-of-care biomarker for patients with suspected neurologic conditions.
• Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids
  June 24, 2026 by Simon M Gray
  CONCLUSIONS: These data suggest that the protein component of red meat may be responsible, in part, for the colitis-promoting effects of this food source and provide insight into dietary factors that may influence IBD severity.
• Hypoxia-mediated epicardial signaling coordinates coronary angiogenesis and myocardial expansion during zebrafish ventricle maturation
  June 22, 2026 by Ku-Chi Tsao
  During cardiac development, the myocardium expands in response to physiological demands to achieve proper cardiac morphology and functional contractility, while simultaneously integrating with the developing coronary vasculature. However, the mechanisms governing this ordered expansion remain poorly understood. Here, we found that regional hypoxia drives local tissue […]
• Development of a Core Outcome Domain Set for Facial Aging
  June 17, 2026 by McKenzie A Dirr
  CONCLUSIONS AND RELEVANCE: The 6 outcome domains identified through a Delphi consensus are recommended for reporting in future facial aging trials to ensure that outcomes that matter most to patients and clinicians are measured and that results are comparable across interventions.
• Chromosomal chaos: understanding aneuploidy associated with assisted reproductive technologies
  June 17, 2026 by Anna Maria McKane
  Pregnancy loss remains a significant challenge for the equine breeding industry, with substantial economic and management consequences. Chromosomal abnormalities have emerged as a central driver of pregnancy loss, particularly during early gestation, highlighting the need to better understand the etiology of this inherent genetic instability. Concurrently, […]
• Correlated gene copy number changes in a seminal fluid protein network in Drosophila
  June 16, 2026 by Jolie A Carlisle
  In Drosophila melanogaster, the male seminal fluid protein Sex Peptide regulates persistent postmating changes in female physiology and behavior. The persistence of long-term postmating responses in females requires Sex Peptide binding to sperm, which is mediated by a network of other seminal fluid proteins. A recent […]
• The Stellate meiotic drive system of Drosophila melanogaster is active in contemporary populations
  June 16, 2026 by Benjamin K McCormick
  Meiotic drivers are selfish elements that bias their own transmission so that they are overrepresented among the functional gametes produced. The selective costs imposed by drivers on their hosts may trigger intragenomic conflict, promoting the evolution of suppressors and fueling an ongoing arms race between drivers […]
• Gait transitions in load-pulling quadrupeds: insights from sled dogs and a minimal spring-loaded inverted pendulum model
  June 16, 2026 by Jiayu Ding
  Quadrupedal animals employ diverse galloping strategies to optimize speed, stability and energy efficiency. However, the biomechanical mechanisms that enable adaptive gait transitions during high-speed locomotion under load remain poorly understood. In this study, we present new empirical and modelling insights into the biomechanics of load-pulling quadrupeds, […]
• Active endothelial and neural regulation of valve biology, health, and disease
  June 15, 2026 by G Janani
  Cardiac valves are complex, living, yet passive structures whose function depends on their ability to withstand and respond to dynamic hemodynamic forces through coordinated interactions among specialized cell types and regulatory systems. Traditional models of valve biology emphasize the roles of valve endothelial cells (VECs), valve […]
• An evolutionary medicine perspective on the design of non-hormonal contraceptives for women
  June 15, 2026 by Ned J Place
  Evolutionary mismatches between the reproductive life histories of women in industrialized societies and their Paleolithic ancestors are established risk factors for gynecological pathologies and breast cancer. In contemporary women, these include earlier menarche, delayed first full-term pregnancy, and reduced or absent lactation. Hormonal contraceptives lower the […]
• Transcriptional response of spermathecal secretory cells to mating and receipt of seminal fluid proteins in Aedes aegypti
  June 15, 2026 by Claudia A S Wyer
  Aedes aegypti mosquitos are major vectors of arboviruses including dengue, yellow fever, Zika, and chikungunya, highlighting the need for innovative control strategies. Females typically mate only once yet store sufficient sperm to produce hundreds of offspring over their lifetime. During mating, males transfer sperm and seminal […]
• Predictions of protein-protein interactions and co-complex models with deep learning
  June 12, 2026 by Zizhao Zhang
  Protein-protein interactions (PPIs) are fundamental to cellular processes, and essential for understanding biological function and disease mechanisms. In this review, we emphasize recent deep learning-based methods for protein interaction study. Focusing on three closely related tasks of proteome-wide PPI prediction, PPI interface prediction, and PPI co-complex […]
• Digital Chromosome Banding Reveals Distinct Spatiotemporal Dynamics and Sexual Dimorphism in Meiotic Silencing
  June 12, 2026 by Yiheng Peng
  In mammals, meiotic silencing of unsynapsed chromatin (MSUC) is initiated by the DNA damage response (DDR) pathway, as marked by γH2AX. During normal male meiosis, MSUC is restricted to the unsynapsed sex chromosomes, a process known as meiotic sex chromosome inactivation (MSCI). While the initiation of […]
• A comparative analysis of promoter-proximal pausing reveals kinetic and distributional dimensions of variation
  June 12, 2026 by Xin Zeng
  Promoter-proximal pausing of RNA polymerase II is a key regulatory checkpoint in metazoan transcription. Despite extensive study of this process, quantitative methods for comparing pausing dynamics across biological contexts have been lacking. Here we introduce a model-based framework for rigorous comparative analysis of both pause-escape kinetics […]
• Individual identity signatures: roles of negative frequency-dependent selection and cognition in shaping and maintaining individuality and trait diversity
  June 11, 2026 by Michael J Sheehan
  Recognition is critical for a wide range of biological interactions from the immune system at the cellular level to individual recognition mediating complex animal social structures. Identity signatures are common features of many animal traits and facilitate self/non-self and individual recognition across diverse taxa. Inherently, identity […]