PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by Jacob OdellLamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery. However, how individual lamin isoforms regulate LBR localization and anchorage remains unclear. Using mouse embryonic fibroblasts lacking all endogenous lamins, we […]
- by Yanlin ZiThe ability to adapt to nutrient stress, such as amino acid limitation, is crucial for cell survival. The mTORC1 complex and integrated stress response (ISR) are two mechanisms that sense the availability of amino acids and regulate protein synthesis. Here, we reveal a new SIRT2-mediated pathway, […]
- by Surya P BhattCONCLUSIONS AND RELEVANCE: In this cohort study, COPD was associated with lower life expectancy, including in adults who never smoked.
- by Chris Ke BaiHistone H3K9me3 silences repetitive elements and represses non-lineage genes during early development, but its role in organogenesis is understudied. Here, we show that H3K9me3 deposition is dynamic during epidermis morphogenesis and essential for lineage diversification. We ablate Suv39h1, Suv39h2, and Setdb1 histone methyltransferases, in the embryonic […]
- by Abdallah AbdelhadyVitrification protocols are widely used for mammalian embryo cryopreservation. Post-warming outcomes are impaired by cryodamage from crystalline intracellular ice, whose formation depends on both the cooling and warming rates. Here, time-resolved X-ray diffraction measurements on bovine embryos indicated that current standard tools and protocols achieved ice-free […]
- by Shiney ChandragantiAlthough immune checkpoint blockade therapy has generated dramatic responses in certain cancer types, breast tumors are largely unresponsive. Epithelial-mesenchymal plasticity leads to the assembly of an immunosuppressive tumor microenvironment and drives resistance of breast tumors to immunotherapies. Importantly, targeting CD73 completely sensitizes quasi-mesenchymal breast tumors to […]
- by Mallikarjun BidarimathHigh-grade serous carcinoma (HGSC) is the most common and aggressive form of ovarian cancer. Advanced HGSCs exhibit pronounced cellular heterogeneity, including a subset of cancer-propagating cells (CPCs, also known as cancer stem cells) that are highly tumorigenic and display stem cell-associated properties such as self-renewal and […]
- by Fikir M MesfinINTRODUCTION: Mesenchymal stem cells (MSCs) have been studied as potential therapeutic agents for various diseases. However, their widespread application has been limited, in part, due to the concern for tumorigenic transformation and lack of longevity in host environments secondary to immune-mediated destruction. Therefore, we set out […]
- by Ariel ShabtayCONCLUSIONS: The Baladi genome is a unique rich mosaic of three domesticated bovine sub-specie lineages. Thus, the Baladi cattle is a mixture already sieved for adaptation to the harsh Mediterranean climate. These findings emphasize the urgent need for conservation efforts to preserve the genetic diversity and […]
- by Laura N Céspedes AriasGenomic data can provide valuable insights into the evolutionary history of rapidly diversifying groups and the genetic basis of phenotypic traits. We performed whole-genome resequencing of the warbler genus Myioborus to investigate the dynamics of its recent diversification in Neotropical mountains. Mitochondrial and nuclear DNA produced […]
- by Kimaya M BakhleEpithelial-mesenchymal plasticity (EMP) is a dynamic cellular process that confers motility to epithelial cells. In carcinomas, this program advances disease progression by promoting therapy resistance, recurrent disease, and spread to distant organ sites. The mechanisms of these clinical consequences are well studied in mouse models. However, […]
- by Laura N Céspedes AriasStudying how genetic variation is structured across space, and how it relates to divergence in phenotypic traits relevant to reproductive isolation, is important for our understanding of the speciation process. We used ddRAD-seq data to examine genetic variation across the distribution of an Andean warbler species […]
- by Jonathon M ThomallaThomalla et al. provide an overview of the conserved and divergent mechanisms of egg activation across animals.
- by Kaiyu JiangGWAS have identified multiple genetic regions that confer risk for juvenile idiopathic arthritis (JIA). However, identifying the single nucleotide polymorphisms (SNPs) that drive disease risk has been impeded by the fact that the SNPs used to identify risk loci are in linkage disequilibrium (LD) with hundreds […]
- by Sarah M BohlingPlants exhibit remarkable biochemical and physiological diversity, and are capable of adapting to a wide range of environmental conditions and stresses. This complexity makes them essential systems for understanding how life responds to a changing climate. Plant proteins are the molecular engines that carry out the […]
- by Cléa S CraneGlutaminase (GLS) catalyzes the hydrolysis of glutamine to produce glutamate, the brain's principal excitatory neurotransmitter. Two de novo gain-of-function mutations in GLS, S482C and H461L, were recently identified in patients with developmental delay, epilepsy, and infantile cataract. These patients exhibited high glutamate and low glutamine concentrations […]
- by Anthony M ChenTriple-negative breast cancer (TNBC) is characterized by aggressive progression and poor prognosis, partly due to abnormal angiogenesis. While the metabolic reprogramming of tumor cells is well characterized, the metabolic regulation of tumor-associated endothelial cells (ECs) remains unclear. Here, we identified the mitochondrial deacylase SIRT5, which has […]
- by Min-Ruei LeeCONCLUSIONS: Higher MBL scores were associated with lower Fe status in NE but not EA females. Greater attention and validated metrics are needed to evaluate MBL and better quantify Fe needs in reproductive-aged females. This trial was registered at clinicaltrials.gov as NCT04198545.
- by Yuqing ChenAquaculture is a fast-growing global industry providing important dietary and economic benefits. Unlike other coastal aquaculture, bivalve aquaculture diet depends on natural productivity rather than introduced nutrients, avoiding detrimental environmental effects. In fact, farmed bivalves provide ecosystem services during grow-out through their water filtration, nutrient sequestration […]
- by Palak ShahCONCLUSION: The transmission potential of respiratory viruses in underventilated homes and healthcare spaces is high, particularly with AC use. Natural ventilation does not reduce R(0) below 1 for super shedders.