PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by Sandra TostaBackground/Objectives. Headache and migraine were exacerbated by light during an episode, with light also serving as a diathesis for pain between episodes. Such interictal photosensitivity has been hypothesized to reflect heightened sensitivity to blue-cyan (BC) light, due to activation of melanopsin-based intrinsically photosensitive retinal ganglion cells […]
- by Zhaofei DuanAlthough plant uptake of micro- and nanoplastics (MNPs) has been well documented, accurately identifying MNP sources and tracking their transport within plants remain major challenges, primarily due to the lack of effective multisource tracing technologies. To fill this gap, we established an ultra-high-resolution multisource tracing approach […]
- by Julia ZhuCystinosis is an autosomal recessive inherited disorder caused by mutations in the CTNS gene, which encodes the highly conserved lysosomal membrane protein, cystinosin. Cystinosin mediates proton-coupled transport of cystine, the oxidized dimer of cysteine. Loss of cystinosin function leads to cystine accumulation in the lysosomal lumen. […]
- by Cade MirchandaniPopulation genomic studies in non-model organisms increasingly depend on whole-genome resequencing, yet translating raw reads into reliable variant callsets remains a practical challenge due to the complexity of multi-step bioinformatics pipelines and the absence of species-specific best practices. Here we present a step-by-step protocol for snpArcher, […]
- by Yakun ZhangCONCLUSION: Although aging was associated with widespread reductions in functional connectivity, older adults who preserved greater intra-network DAN connectivity and stronger inter-network connectivity between the DAN and the DMN, SN, and FPN exhibited better executive function. These findings suggest that maintaining DAN-centered communication may contribute to […]
- by Alexandra Sexton-OatesCONCLUSIONS: Overall, our findings unify previously proposed molecular classifications and refine the lung cancer map by revealing novel tumour phenotypes with potential implications for prognosis and therapeutic management.
- by Maya S SchlesingerPURPOSE OF REVIEW: Cell-free nucleic acids (cfNAs) in plasma and urine have emerged as noninvasive biomarkers for monitoring kidney transplant health. This review summarizes recent advances in the development of cell-free DNA (cfDNA) and cell-free RNA (cfRNA) assays for immune and infection-related complications, and discusses their […]
- by Analise D CoonIn this issue, Keegan et al. (https://doi.org/10.1083/jcb.202512053) uncover molecular dynamics of biphasic centromere histone assembly in the Drosophila male germline: initially mitotic-like, then chaperone independent. These findings highlight germline-specific adaptations in centromere assembly that deviate from the somatic cell paradigm.
- by Alexis DziubekGenetic variation is a major cause of disease susceptibility, and sequence variants can change both protein function and stoichiometry. Though posttranscriptional regulation is a major component of mammalian gene expression control, single-nucleotide polymorphisms (SNPs) within 3' untranslated regions (UTRs) remain an underexplored source of variation impacting […]
- by Jinjing LiuFusobacterium nucleatum is an anaerobic Gram-negative bacterium associated with periodontal disease and colorectal cancer. Outer membrane vesicles (OMVs) produced by F. nucleatum are nanoscale lipid vesicles enriched with immunogenic and virulence-associated proteins, making them promising candidates for vaccine development. This protocol describes a comprehensive workflow for […]
- by Qing ZhangLegionella pneumophila infects and replicates within protozoa and macrophages in a specialized compartment termed the Legionella-containing vacuole. To establish this niche, the bacterium delivers more than 350 effector proteins through its type IV secretion system to modulate host pathways and prevent phagolysosome fusion. Here, we identify […]
- by Andreas StephanouCanine acanthomatous ameloblastoma (CAA) is a locally invasive benign oral neoplasm that is difficult to distinguish from canine oral squamous cell carcinoma (COSCC) due to overlapping features. Previous studies using bulk RNA sequencing (RNA-seq) have demonstrated pronounced differences in programs related to hypoxia and cell proliferation. […]
- by Christopher MellorFolate metabolites are chemically unstable: spontaneous decomposition releases formaldehyde, a genotoxin in blood stem cells and a human carcinogen. Despite this, folic acid consumption frequently exceeds the Recommended Dietary Allowance and is prescribed at high doses for patients with blood disorders. However, the impact of excess […]
- by Jai LakeParent-offspring associations provide the basis for more complex care and breeding systems. One proximate mechanism by which parental behavior is facilitated across animal taxa is via nonapeptide hormones such as arginine vasotocin (AVT). However, existing research largely comes from obligately social species, and whether such mechanisms […]
- by Sina NasrollahianColorectal cancer (CRC) is a multifactorial disease influenced by genetic, environmental, and microbial factors. Among gut microbiota, pks^(+)Escherichia coli has emerged as a key contributor to colorectal carcinogenesis through the production of colibactin, a genotoxic secondary metabolite. Colibactin induces DNA damage by forming interstrand crosslinks and […]
- by Chia-Hsin HsuTargeted kinase inhibitors induce marked tumor regressions but are limited by the emergence of drug-tolerant residual disease and resistance. Although tumor-intrinsic and adaptive immune mechanisms have been extensively studied, a better understanding of the contribution of innate immunity to targeted therapy durability is needed to devise […]
- by Cailin E WinokurWhile the gross dental anatomy of the Virginia opossum (Didelphis virginiana) has been described, the radiographic appearance of the dentition and the prevalence of dental and oral pathology have not been comprehensively evaluated. The objective of this study was to characterize the intraoral radiographic dental anatomy […]
- by Paul R MunnFunctional element annotations are critical tools used to provide insight into the molecular processes governing cell development, differentiation, and disease. Run-on and sequencing assays measure the production of nascent RNAs and can provide an effective data source for discovering functional elements. However, the accurate inference of […]
- by Catherine RenaudinThe objectives of this clinical case report were to highlight the value of late transrectal ultrasound examination for assessing fetal presentation, position and posture and to describe the management of a case of malposture associated with musculoskeletal and cerebellar abnormalities, including its in utero ultrasound diagnosis […]
- by Huihui LiuRNA pesticides have garnered considerable attention in pest management due to their exceptional selectivity, environmental safety, and flexible design. They interfere with essential physiological processes in pests by silencing key genes, thereby achieving effective pest control. Moreover, RNA pesticides can target genes related to detoxification enzymes […]