PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by Jason D ChobirkoTransposable elements (TEs) comprise about half of the human and mouse genomes and contribute to gene regulation during immune responses. However, how TEs acquire cis-regulatory functions during immune cell development remains poorly understood. Here, we analyzed hundreds of datasets profiling chromatin accessibility, gene expression, transcription factor […]
- by Linru JiangDiabetic wounds are a severe and prevalent complication of diabetes, often resulting in high healthcare costs and an increased risk of amputation. Infection and insufficient angiogenesis are two primary factors that severely impede diabetic wound healing. In this study, we developed a potent antifouling and antimicrobial […]
- by Peiwei ChenIn Metazoa, transposon expression is suppressed by the piRNA pathway, and disruption of this pathway leads to rampant transposon expression. However, it remains unclear whether increased transposon expression results in actual transposition, and if so, which and how frequently transposons mobilize upon piRNA loss. Here, we […]
- by Keonwook NamThe diversity of programmable DNA architecture offers exceptional design flexibility, yet the limited bioapplication of conventional DNA assemblies constrains their practical utility. Here, we introduce a strategy that employs silver nanoclusters (AgNCs) as a molecular "glue" to cross-link DNA nanostructures, significantly enhancing their biostability. Our design […]
- by Luciana P de AlmeidaMaternal and paternal homologous chromosomes recognize each other and pair during meiosis to ensure accurate chromosome segregation. However, the mechanisms that drive chromosome pairing and their regulation remain poorly understood. To investigate this, we develop a fluorescence reporter-operator system based on the lac operator-lac repressor system, […]
- by Martin V HamannPeople living with HIV (PLWH) on antiretroviral therapy (ART) accumulate primarily defective proviral sequences in genomes of often clonally expanded CD4 + HIV-1 target cells. The majority of viral-derived DNA is transcriptionally active and preferentially found at distinct genomic loci suggesting a selective process driven by […]
- by A GihawiMicrobial constituents in the gastrointestinal tract, the urine and prostate tissue are being linked with clinical differences in prostate cancer, and a recent meta-analysis has linked periodontal disease to this cancer. Several hypotheses exist regarding how specific bacteria can contribute towards the development of prostate cancer. […]
- by Nilay YapiciAnimals must quickly learn to avoid food that makes them sick. A recent study in Drosophila melanogaster shows that ingesting pathogenic bacteria triggers dopamine release from fat cells that alters odor responses in the fly brain and switches feeding preference toward non-pathogenic food.
- by Robert JordanThe 39th International Conference on Antiviral Research (ICAR), hosted by the International Society for Antiviral Research (ISAR), took place April 27-May 1, 2026, at the Cubex Centrum Praha in Prague, Czech Republic. The annual meeting brought together scientists from academia, industry, government, and public health to […]
- by Luca A HateganAlzheimer's disease (AD) disproportionately affects women, yet mechanisms underlying this sex difference remain unclear. Histone variants are overrepresented components of aging neuronal chromatin, but their contribution to AD is unknown. Here, we identify the histone variant H2A.Z as a sex-specific regulator of AD in the postmortem […]
- by You ChenDivergent transcription is a critical marker of active transcriptional regulatory elements (TREs), including enhancers and promoters, in mammals. However, distal elements with unidirectional transcriptional patterns are often overlooked, leaving their identity and function poorly understood. Here, we perform a systematic comparison between divergent and unidirectional elements, […]
- A supergene and genomic mosaicism are associated with phenotypic evolution in Galápagos tree finchesby Matteo Sebastianelli ArbelaezAdaptive radiations provide powerful models to study the origins of phenotypic novelty and species diversity. Darwin's finches constitute a classic example of adaptive radiation, in which beak morphology is a key trait related to fitness. Here, we focus on Camarhynchus tree finches by analyzing whole genomes […]
- by Jianing XuCancer genomics studies have implicated combined loss of VHL and TSC1 as sufficient to initiate clear cell renal cell carcinoma (ccRCC) in humans. Here, we engineered a mouse model with kidney-specific deletion of Vhl and Tsc1. Vhl ^(F/F) Tsc1 ^(F/F) Ksp-Cre ^(+) mice developed multifocal renal […]
- by Liqing HuangLymphatic dysfunction drives severe and often intractable human diseases, yet the cellular mechanisms that establish functional lymphatic vasculature remain poorly understood. In the intestine, lacteals are specialized lymphatic vessels that absorb dietary lipids and rely on surrounding villus smooth muscle to propel lymph, forming the muscular-lacteal […]
- by Timothy S JohnstonVirus exposure history, particularly first exposure, is believed to shape vaccine efficacy and infection susceptibility; however, evidence for mechanistic links between immune responses in individuals and epidemiological outcome in populations is scarce. Recent co-circulation of SARS-CoV-2 variants XFG and BA.3.2 has revealed a striking enrichment in […]
- by Yuan HouDespite prolific genomic data from individuals with Alzheimer's disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of European ancestry and 7 for African […]
- by Allen F SchroederThe majority of metabolic pathways rely on the production of activated electrophilic intermediates, e.g., coenzyme-A esters, and their chemical structures and abundances are central to understanding enzyme function and biochemical mechanisms. However, most electrophilic metabolites are lost in traditional metabolomic analysis and thus remain poorly characterized. […]
- by Laura D BertolaMulti-taxa genomic data offer valuable opportunities to assess the extent to which co-distributed taxa exhibit parallel responses to shared environmental regimes and climatic history. In this study, we use genome-environment associations (GEA) to examine how present and past climate may have shaped spatial patterns of adaptive […]
- by Yifan LiBiobank-scale genomic analyses are increasingly constrained by computational costs, as hundreds of thousands to millions of samples and variants must be analyzed together. The genotype representation graph (GRG) compactly encodes population genetic variation to accelerate computation, but the current approach does not exploit modern accelerator architectures. […]
- by Risa YamazakiA central challenge in neuroscience research is to elucidate how distinct neuronal types coordinate to produce complex behaviors, which requires linking the molecular identity of neuronal types with their connectivity and activity in behaving animals. Here, we present a protocol for integrating spatial gene-expression profiling with […]