PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by Allen F SchroederThe majority of metabolic pathways rely on the production of activated electrophilic intermediates, e.g., coenzyme-A esters, and their chemical structures and abundances are central to understanding enzyme function and biochemical mechanisms. However, most electrophilic metabolites are lost in traditional metabolomic analysis and thus remain poorly characterized. […]
- by Laura D BertolaMulti-taxa genomic data offer valuable opportunities to assess the extent to which co-distributed taxa exhibit parallel responses to shared environmental regimes and climatic history. In this study, we use genome-environment associations (GEA) to examine how present and past climate may have shaped spatial patterns of adaptive […]
- by Risa YamazakiA central challenge in neuroscience research is to elucidate how distinct neuronal types coordinate to produce complex behaviors, which requires linking the molecular identity of neuronal types with their connectivity and activity in behaving animals. Here, we present a protocol for integrating spatial gene-expression profiling with […]
- by Carmen R SmithThe translocator protein (TSPO) is a mitochondrial outer membrane protein enriched in lipid-metabolic tissues, including white adipose tissue (WAT), but its physiological role in adipocytes remains poorly defined. Building on prior work that demonstrated a role for TSPO in mitochondrial fatty acid oxidation, we investigated whether […]
- by Noam Zuela-SopilniakCONCLUSIONS: Our findings support a model in which nuclear envelope rupture in cKO cardiomyocytes triggers cytosolic DNA sensing pathways and maladaptive cell-cell communication with fibroblasts and immune cells, driving inflammation, fibrosis, and cardiac dysfunction. The work presented here points to novel strategies for treating LMNA-dilated cardiomyopathy.
- by Sushant PotdarIn many insects, females exhibit behavioral changes after mating. This plasticity can be mediated by interactions between male-derived seminal fluid proteins (SFPs) and the female nervous system. The Drosophila melanogaster seminal fluid protein Sex Peptide (SP) causes mated females to sleep less during the day and […]
- by Wilfred LeungHigh-grade canine B-cell lymphoma (cBCL) is a spontaneous cancer in dogs with similar pathologic features as human diffuse large B-cell lymphoma (DLBCL). The value of comparative oncology to both dogs and humans has long been recognized, but the progress in cBCL research has been hampered by […]
- by Pu GaoTransposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum contagiosum virus (MCV), which were likely acquired through long interspersed nuclear element 1 (LINE-1 or L1)-mediated retrotransposition during […]
- by Atahan DurbasCONCLUSION: VPAs increase in the sitting position, particularly in the lower thoracic and proximal lumbar spine. The T10PA-L1PA relationship reverses across postures: T10PA is lower than L1PA in standing but equal to or greater in sitting, highlighting TLJ as the key transition. These adaptations are strongly […]
- by Sharada GopalThe nuclear hormone receptor NHR-49, a homolog of mammalian PPARα and HNF4α, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here, we examine the role of NHR-49 in reproduction, including oocyte activation and ovulation. Loss of NHR-49 causes inappropriate […]
- by George C HansenBACKGROUND: Surgical site infections (SSIs) following canine tibial plateau leveling osteotomy (TPLO) represent a significant clinical concern. A universal estimate of SSI incidence and identification of predisposing factors can guide preventive strategies.
- by Qian QinCONCLUSION: Spatial transcriptomics thus revealed novel insights into key differences in the pathophysiology of ICI-AIN versus ICI-ATN, with IFN-γ-producing CD8^(+) T cells as potential drivers of ICI-AIN.
- by Nick ChaterOur commentators have broadly welcomed the notion of social tinkering, while also offering a range of suggestions, refinements, and potential challenges. In our response, we clarify the concept of social tinkering, sharpen our account of the six stages of cultural evolution, consider whether additional mechanisms are […]
- by Aminat M IbrahimMaintaining a confluent, antithrombotic endothelium on cardiovascular biomaterial surfaces remains a major barrier to long-term hemocompatibility, as endothelial cells (ECs) rapidly denude under supraphysiological shear in prosthetic devices. Here, we hypothesized that mesoscale surface geometry (∼100-200µm) could reorganize near-wall hemodynamics, preserving endothelial coverage and function under […]
- by Hannah SylvesterFibrocytes represent a distinct somatic cell type derived from peripheral blood leukocytes, first described as spindle-shaped adherent cells with dual hematopoietic and mesenchymal features. Although fibrocytes were identified in early descriptive studies across several mammalian systems, most of this work predated modern molecular approaches, and the […]
- by Fanju W MengAlterations in chromatin state, mediated through histone modifications and the incorporation of histone variants, are fundamental to establishing transcriptional networks and cell identity. Recent advances in low-input epigenome profiling methods, such as CUT&Tag and CUT&RUN, have enabled the study of chromatin states from very limited starting […]
- by Sri Lakshmi Sravani DevarakondaPrecision nutrition is the personalization of dietary recommendations based on characteristics such as genetics, the microbiome, lifestyle, environment, and baseline metabolic state. One potential basis for the development of guidelines is the characterization of gene-diet interactions. In this narrative review, we evaluate the published literature reporting […]
- by Connor E OwensCONCLUSION: Ubiquitous nmrHas2 expression did not attenuate AHL in C57BL/6 mice despite previously reported benefits for other aging phenotypes. These findings contrast with CR, suggesting that vHMM-HA and CR influence aging through distinct mechanisms.
- by Eli SteinCONCLUSIONS: The cost or inpatient burden of treating patients with orbital fractures is greater in patients with traffic injuries, ≥4 facial fractures, and operative management.
- by Ajay SubramanianCONCLUSION: Tumor-informed, personalized profiling enables sensitive ctDNA detection and quantitative monitoring in localized STS, providing independent prognostic information across the perioperative course. These findings support prospective ctDNA-guided interventional trials in STS.