PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by George C HansenBACKGROUND: Surgical site infections (SSIs) following canine tibial plateau leveling osteotomy (TPLO) represent a significant clinical concern. A universal estimate of SSI incidence and identification of predisposing factors can guide preventive strategies.
- by Nick ChaterOur commentators have broadly welcomed the notion of social tinkering, while also offering a range of suggestions, refinements, and potential challenges. In our response, we clarify the concept of social tinkering, sharpen our account of the six stages of cultural evolution, consider whether additional mechanisms are […]
- by Qian QinCONCLUSION: Spatial transcriptomics thus revealed novel insights into key differences in the pathophysiology of ICI-AIN versus ICI-ATN, with IFN-γ-producing CD8^(+) T cells as potential drivers of ICI-AIN.
- by Aminat M IbrahimMaintaining a confluent, antithrombotic endothelium on cardiovascular biomaterial surfaces remains a major barrier to long-term hemocompatibility, as endothelial cells (ECs) rapidly denude under supraphysiological shear in prosthetic devices. Here, we hypothesized that mesoscale surface geometry (∼100-200µm) could reorganize near-wall hemodynamics, preserving endothelial coverage and function under […]
- by Hannah SylvesterFibrocytes represent a distinct somatic cell type derived from peripheral blood leukocytes, first described as spindle-shaped adherent cells with dual hematopoietic and mesenchymal features. Although fibrocytes were identified in early descriptive studies across several mammalian systems, most of this work predated modern molecular approaches, and the […]
- by Fanju W MengAlterations in chromatin state, mediated through histone modifications and the incorporation of histone variants, are fundamental to establishing transcriptional networks and cell identity. Recent advances in low-input epigenome profiling methods, such as CUT&Tag and CUT&RUN, have enabled the study of chromatin states from very limited starting […]
- by Sri Lakshmi Sravani DevarakondaPrecision nutrition is the personalization of dietary recommendations based on characteristics such as genetics, the microbiome, lifestyle, environment, and baseline metabolic state. One potential basis for the development of guidelines is the characterization of gene-diet interactions. In this narrative review, we evaluate the published literature reporting […]
- by Connor E OwensCONCLUSION: Ubiquitous nmrHas2 expression did not attenuate AHL in C57BL/6 mice despite previously reported benefits for other aging phenotypes. These findings contrast with CR, suggesting that vHMM-HA and CR influence aging through distinct mechanisms.
- by Eli SteinCONCLUSIONS: The cost or inpatient burden of treating patients with orbital fractures is greater in patients with traffic injuries, ≥4 facial fractures, and operative management.
- by Ajay SubramanianCONCLUSION: Tumor-informed, personalized profiling enables sensitive ctDNA detection and quantitative monitoring in localized STS, providing independent prognostic information across the perioperative course. These findings support prospective ctDNA-guided interventional trials in STS.
- by Yuke XieCONCLUSIONS: 25(OH)D(3) biofortification of chicken and eggs prevented the seasonal decline in serum 25(OH)D observed in healthy young adults not taking vitamin D(3) supplements but was not as effective as a daily 1000-IU vitamin D(3) supplement.
- by Xincheng WuViral 2A oligopeptides drive an unusual ribosome recoding event in which peptide-bond formation fails at a conserved PG↓P motif, producing two discrete proteins without canonical termination. Despite decades of study, the molecular basis of 2A-mediated peptide-bond skipping remains poorly understood. Here, we combine quantitative 2A reporters […]
- by Maren N VitousekA continent-wide analysis of banding data shows that North American birds aren't declining for a single shared reason. Each bird species responds to its own specific environmental triggers, and those triggers can be predicted from a species' traits.
- by Michael J SheehanA new study identifies the chemical features of cat urine that provide distinctive, individual signatures. The branched-chain fatty acids that confer a chemical nametag for cat urine represent a novel system previously undescribed in mammals.
- by Bingsen ZhangProtein posttranslational modifications (PTMs) play a central role for regulating protein function and cellular processes, with many PTMs arising from reactions with electrophilic metabolites. Here we extend the known landscape of PTMs with the identification of "lysine C(3)-iminylation," the conjugation of protein lysine residues with propionaldehyde. […]
- by Tejas SubramanianCONCLUSIONS: Radiographic FS, even when deemed asymptomatic, was associated with worse long-term functional outcomes and higher revision rates following minimally invasive decompression. These findings underscore the need for careful preoperative assessment and surgical planning, particularly for patients with moderate-to-severe FS, to optimize long-term outcomes.
- by Indu SubramanianGastrointestinal dysfunction represents a pervasive and disabling group of non-motor symptoms that often go unrecognized and untreated in Parkinson's Disease(PD). These symptoms can affect levodopa responsiveness, quality of life, and nutritional status. Because gastrointestinal symptoms may be highly stigmatizing or embarrassing, some patients-particularly those from certain […]
- by Sandra TostaBackground/Objectives. Headache and migraine were exacerbated by light during an episode, with light also serving as a diathesis for pain between episodes. Such interictal photosensitivity has been hypothesized to reflect heightened sensitivity to blue-cyan (BC) light, due to activation of melanopsin-based intrinsically photosensitive retinal ganglion cells […]
- by Zhaofei DuanAlthough plant uptake of micro- and nanoplastics (MNPs) has been well documented, accurately identifying MNP sources and tracking their transport within plants remain major challenges, primarily due to the lack of effective multisource tracing technologies. To fill this gap, we established an ultra-high-resolution multisource tracing approach […]
- by Julia ZhuCystinosis is an autosomal recessive inherited disorder caused by mutations in the CTNS gene, which encodes the highly conserved lysosomal membrane protein, cystinosin. Cystinosin mediates proton-coupled transport of cystine, the oxidized dimer of cysteine. Loss of cystinosin function leads to cystine accumulation in the lysosomal lumen. […]