PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by Kaho WatanabeBitterness is one of the five recognized basic tastes. Although many groups have examined bitter taste through human sensory evaluation, there are few cases in which its taste quality and temporal characteristics have been comprehensively evaluated. In this study, we conducted sensory evaluations to assess the […]
- by Conor C TaffCoping with challenges often requires maintaining performance during poor conditions (robustness) and reestablishing normal performance following disturbance (resilience). Trade-offs between performance under normal and challenging conditions may generate variation in stress-coping capacity, but there are few empirical data to test this idea from wild populations. We […]
- by Yuanliang LiMutations in a specific protein called calcium-activated nucleotidase 1 (Cant1) cause skeletal deformities, but the role of Cant1 in these deformities remains unclear. This study shows how Cant1 acts as a key regulator of bone and cartilage health. We found that Cant1 binds to and stabilizes […]
- by Isabel K KimGene drives offer revolutionary potential for the management of problematic plant populations, such as invasive weeds and herbicide-resistant species, by rapidly spreading desired genetic alterations. Two recent studies have provided experimental demonstrations of engineered CRISPR gene drive systems in plants (CAIN and ClvR). However, the successful […]
- by Zhaoxi ZhangGenome annotation currently requires performing dozens of molecular assays in hundreds of cell and tissue samples, an expensive endeavor which is impractical to replicate across all species and conditions of interest. Here, we introduce BioSeq2Seq, a deep learning framework that infers cell-line-specific molecular assays widely used […]
- by Chase HoldenerFinding correlations in spatial gene expression is fundamental in spatial transcriptomics, as co-expressed genes within a tissue are linked by regulation, function, pathway, or cell type. Yet, sparsity and noise in spatial transcriptomics data pose significant analytical challenges. Here, we introduce Smoothie, a pipeline that denoises […]
- by Aminat M IbrahimMaintaining a confluent, antithrombotic endothelium on cardiovascular biomaterial surfaces remains a major barrier to long-term hemocompatibility, as endothelial cells (ECs) rapidly denude under supraphysiological shear in prosthetic devices. Here, we hypothesized that mesoscale surface geometry (~100-200 μm) could reorganize near-wall hemodynamics, preserving endothelial coverage and function […]
- by Xiaomu WeiAlzheimer's disease (AD) is an irreversible neurodegenerative disease defined by its molecular hallmarks – amyloid beta peptide plaques and neurofibrillary Tau tangles. Despite significant progress that has been made in uncovering a large number of genetic risk factors through extensive genomic sequencing and genetic studies, the […]
- by Alexa BaradBACKGROUND: Over 100 genetic variants are linked to iron (Fe) biomarkers in European populations, but their effects on non-heme Fe absorption remain unknown. Additionally, despite the higher body Fe burden observed in East Asian (EA) individuals, the genetic factors influencing Fe absorption in this population remain […]
- by Cole KwasCONCLUSION: Patients with inflammatory arthritis undergoing minimally invasive lumbar fusion have similar clinical outcomes as compared with controls.
- by Meisam ZaferaniDuring migration through the female reproductive tract, sperm undergo physiological changes known as capacitation, including a motility transition termed hyperactivation. Hyperactivation is essential for various aspects of fertilization, particularly effective migration within the tract. However, how hyperactivation facilitates this migration remains elusive. Here, we profiled bull […]
- by Ashley N Kamimae-LanningDNA damage and mutations in hematopoietic stem cells (HSCs) enable clonal hematopoiesis (CH). Such damage occurs across a lifetime, but its origins remain unknown. Here, we demonstrate that endogenous formaldehyde causes HSC attrition and subsequently CH. We generated conditional mouse models lacking formaldehyde detoxification and Fanconi […]
- by Julia ZhuCystinosis is an autosomal recessive inherited disorder caused by mutations in the CTNS gene, which encodes the highly conserved transmembrane protein cystinosin, a proton/cystine co-transporter at the lysosome membrane. However, reduction of cystine load in the lysosomes is insufficient to treat key disease symptoms, indicating that […]
- by Cuiping GuoThe development of tissue-engineered heart valves (TEHVs) remains a challenge worldwide. In this study, a series of double-crosslinked methacrylated (MA) carrageenan (CA)/MA gelatin hydrogels loaded with heparin (CA/Gel@Hep) were developed as potential materials for TEHV. CA/Gel@Hep hydrogels with different concentrations of heparin were fabricated, and their […]
- by Alaa R FarghliFibrolamellar carcinoma (FLC) is a rare malignancy disproportionately affecting adolescents and young adults with no curative therapy. FLC is characterized by thick stroma, which has long suggested an important role of the tumor microenvironment. Over the past decade, several studies have revealed aberrant chromatin activity and […]
- by Tongcui MaImmunological mechanisms regulating HIV rebound after antiretroviral therapy (ART) interruption remain unclear. We examined relationships between host factors, HIV reservoir, and HIV time-to-rebound after analytical treatment interruption (ATI) by characterizing pre-ATI peripheral blood mononuclear cells (PBMCs) from 75 ART-suppressed people with HIV (PWH) using high-parameter methods. […]
- by Tudorita TumbarIn many non-skin tissues, vascular endothelial cells (VECs) are increasingly recognized as integral components of stem cell niches engaged in bidirectional molecular crosstalk, regulating stem cell behavior through angiocrine signaling. In the skin, however, the nature and physiological relevance of VEC cues influencing epithelial stem cells […]
- by Yngwie A NielsenSpeakers in conversation reuse each other's words, structures, meanings, sounds and gestures. This phenomenon-known as conversational alignment-is regarded as a cornerstone of successful communication and has garnered attention from researchers studying individual differences. The concept of individual differences in alignment, however, lacks both a theoretical and […]
- by Plansky HoangThe human heart, originating from the splanchnic mesoderm, is the first functional organ to develop, co-evolving with the foregut endoderm through reciprocal signaling. Previously, cardioid models offered new insights on cardiovascular cell lineages and tissue morphogenesis during heart development, while mesoderm-endoderm crosstalk remain incompletely understood. Here, […]
- by Morgan C SlevinWild animals experience daily fitness challenges, and the resulting stress responses can disrupt an animal’s gut microbiome. Given the links between health and microbiome composition, it is essential to understand how challenges affect microbial communities. We showed that a fitness challenge significantly alters the cloacal microbiome […]