PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by Seh Ri OhMicrobead-based modular systems offer significant potential for biofabrication strategies in tissue regeneration. In this study, we present a tunable microfluidic cryogel microbead (MCB) platform that enables injectable, modular assembly of cells and tissue-specific regeneration. The MCBs are designed to incorporate diverse ECM compositions, porosities, and bioceramic […]
- by Tegan S HoranMeiotic recombination generates crossovers (COs), reciprocal exchanges between homologous chromosomes critical for accurate chromosome segregation. Inappropriate CO frequency and distribution drive aneuploidy in human oocytes, with error rates up to 10-fold higher than in sperm despite females exhibiting higher CO frequencies. COs form in the context […]
- by Mihir S DekhneCONCLUSIONS: Early surgery for ACSCC is not cost-effective under current progression estimates but may be justified in high-risk patients with rapid progression. These findings support a risk-stratified approach, emphasizing early intervention only for patients with predictive biomarkers or imaging features of deterioration.
- by Leah N RamsaranCONCLUSIONS: Commonly used reference genes (ACTB, GAPDH, B2M) for RT-qPCR normalization were amongst the least stably expressed genes in equine corpus luteum samples of pregnant and nonpregnant mares at days 11 and 13 of gestation. The most stably expressed putative reference genes using 3 different analysis […]
- by Masroor SagheerUterine luminal fluid influences embryonic development and the subsequent phenotype of offspring, yet its detailed metabolomic composition remains poorly characterized. Here, minimally invasive transcervical techniques were employed to collect neat uterine fluid from postpartum dairy cows and cyclic beef cows to allow for metabolomic profiling via […]
- by David W BuchholzEnveloped viruses are significant zoonotic disease threats with the potential to cause global pandemics. We identified a class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped viruses. Multidisciplinary approaches revealed that XM compounds alter the viral membrane lipid chemical composition, enhance membrane order […]
- by Moona HuttunenThe nucleolus is a biomolecular condensate essential for ribosome biogenesis and cellular stress response, and it is a key target for many DNA viruses. However, little is known about how autonomous parvovirus infection impacts the nucleolus. Here, we used ten-fold robust expansion microscopy, cryo soft X-ray […]
- by Joydeep ChakrabortyFolate-mediated one-carbon metabolism is implicated in several pathologies including neural tube defects (NTDs), cancer, and neurodegenerative disorders, whereas diabetes is associated with NTDs and peripheral neuropathy (PN). The development of peripheral neuropathy was assessed in Shmt1^(+/-) and Shmt1^(-/-) mice, which are models of human folic acid-responsive […]
- by Jiaqi ZouThis review provides a comprehensive analysis of manganese (Mn) metabolism and its regulatory roles across multiple biological levels. By examining Mn homeostasis mechanisms, including Mn absorption, excretion, distribution, and transport across the intestines, liver, and brain, this work highlights the integrative nature of Mn physiology. Additionally, […]
- by Tejas SubramanianCONCLUSION: There is moderate evidence suggesting ESP blocks are effective in improving postoperative pain and reducing opioid requirements in pediatric patients undergoing posterior spinal fusion. These findings support the integration of ESP blocks into multimodal analgesia protocols for pediatric scoliosis correction.
- by Anthony PajakBackground/Objectives: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) and SpineSage^(TM) risk calculators are automated online tools to predict short-term complications for surgical procedures. The objective of this study was to assess the validity of ACS-NSQIP and SpineSage^(TM) risk calculators to predict short-term […]
- by Rolfe M RadcliffeCONCLUSIONS: Application of TRAUMAGEL followed by direct pressure decreased time to hemostasis and severity of hemorrhage compared to direct pressure alone.
- by Kaiyu JiangGWAS have identified multiple genetic regions that confer risk for juvenile idiopathic arthritis (JIA). However, identifying the single nucleotide polymorphisms (SNPs) that drive disease risk has been impeded by the fact that the SNPs used to identify risk loci are in linkage disequilibrium (LD) with hundreds […]
- by Jooyoung ParkEmbryonic heart development depends on coordinated interactions between cellular programs, molecular signaling, and biomechanical forces, yet how mechanical cues shape cellular and molecular pathways remains incompletely understood. We perturbed cardiac blood flow by partial left or right atrial ligation (LAL/RAL) in chick embryos, generating chamber-specific hemodynamic […]
- by Zachary GershonThe genetic factors and resulting neural circuit physiology driving variation in attention are poorly understood. Here we took an unbiased forward genetics approach to identify genes of large effect on attention. We studied 200 genetically diverse mice and, through genetic mapping, identified a small locus on […]
- by Francesco BeghiniThe gut microbiome is integral to human health, yet research data to date have emphasized industrialized populations. Here, we performed large-scale shotgun metagenomic sequencing on 1,893 individuals from rural Honduras, providing the most comprehensive microbiome dataset from Central America. We identify a distinct microbial composition enriched […]
- by Jaime D Ortiz-PacharThe Galápagos Islands face threats from human activities and climate change, with significant consequences for native fauna like the brown sea cucumber, Isotichopus fuscus (Ludwig, 1875). Once abundant in the region's shallow coastal waters, this species has suffered dramatic population declines due to overexploitation and is […]
- by Alexandra G ChivuPromoter-proximal pausing of RNA polymerase (Pol) II is a key regulatory step during transcription. Despite the central role of pausing in gene regulation, we do not understand the evolutionary processes that led to the emergence of Pol II pausing or its transition to a rate-limiting step […]
- by Matthew N ZippleAppropriate classification of a novel stimulus as threatening or benign depends on a repertoire of prior environmental experiences involving challenge, risk, and opportunity¹^(,)². Without this library, individuals may classify harmless stimuli as dangerous – a hallmark of generalized anxiety¹^(,)². In humans, insufficient exposure to uncertainty or […]
- by Fiona HarnischfegerCONCLUSIONS: Overall, data demonstrate that obesity has a persistent effect on taste buds long after excess weight is lost.