PubMed Vertebrate Genomics Feed
This is an RSS feed from PubMed (https://pubmed.ncbi.nlm.nih.gov/) of the 20 most recent papers published by CVG Members.
- by Min-Ruei LeeCONCLUSION: Higher MBL scores were associated with lower Fe status in NE but not EA females. Greater attention and validated metrics are needed to evaluate menstrual blood losses and better quantify Fe needs in reproductive-aged females.
- by Palak ShahCONCLUSION: The transmission potential of respiratory viruses in underventilated homes and healthcare spaces is high, particularly with AC use. Natural ventilation does not reduce R(0) below 1 for super shedders.
- by Yuqing ChenAquaculture is a fast-growing global industry providing important dietary and economic benefits. Unlike other coastal aquaculture, bivalve aquaculture diet depends on natural productivity rather than introduced nutrients, avoiding detrimental environmental effects. In fact, farmed bivalves provide ecosystem services during grow-out through their water filtration, nutrient sequestration […]
- by Abigail R WilliamsonAge-related skeletal muscle deterioration is a commonly reported disability among older adults, attributed to several factors including mitochondrial dysfunction, a major hallmark of aging. Therapies to attenuate or reverse mitochondrial decline are limited. Despite identified positive relationships between vitamin B12 (B12) and mitochondrial biology, the impact […]
- by Jia-Cheng YangCONCLUSIONS: In conclusion, our findings support a contributory role for SELENOS in ER stress-related responses and apoptosis-associated signaling, providing insights into Se deficiency-induced NMD and suggesting SELENOS as a potential therapeutic target for muscle disorders under stress conditions.
- by Cybelle TabilasFollowing thymic egress, CD8^(+) T cells undergo post-thymic maturation to transition from recent thymic emigrants (RTEs) to mature naive T cells. Although RTEs are phenotypically and functionally distinct from mature naive CD8^(+) T cells, most studies on RTEs have been performed in adults. As a result, […]
- by Jiadai HuangThe transcription factor (TF) regulatory network in Pseudomonas aeruginosa is complex and involves multiple regulators that respond to various environmental signals and physiological cues by regulating gene expression. However, the biological functions of at least half of its 373 putative TFs remain uncharacterised. Herein, chromatin immunoprecipitation […]
- by Daryl J PhuongHigh-grade serous ovarian carcinoma (HGSC) is the sixth leading cause of cancer-related death among women. Most tumors arise from the Fallopian tubal epithelium (TE), exhibit numerous mutations, and present heterogenous pathological features. However, the contribution of specific mutation combinations to cellular transformation, pathological phenotype and chemotherapeutic […]
- by Robert A López-AstacioEmergence of epidemic viruses in new hosts threatens both human and other animal populations, and often involves virus evolution to overcome barriers that normally prevent efficient infection and spread in that host. After transfer the separated viruses will evolve in parallel as they spread within the […]
- by Maegwin BonarHow adaptive and non-adaptive processes interact to shape urban-rural clines remains a fundamental question in urban evolution. Here, we integrate whole-genome sequencing, demographic modelling and forward-in-time simulations to test how natural selection in urban and rural environments interacts with non-adaptive forces to maintain a pigmentation cline […]
- by Mumingjiang MunishaAbnormal placentation drives many pregnancy-related pathologies and poor fetal outcomes, but the underlying molecular causes are understudied. Here, we show that persistent replication stress due to mutations in the MCM2-7 replicative helicase disrupts placentation and reduces embryo viability in mice. MCM-deficient embryos exhibited normal morphology, but […]
- by Brittany E SchutrumMorphological changes of spheroids and organoids are widely used as in vitro indicators of healthy and diseased tissue functions; however, quantitative methods to classify spheroid and organoid morphology are limited. In clinical breast imaging, radiologists use tumor shape as a prognostic marker, with irregular margins associated […]
- by Zenna SolomonCONCLUSIONS: Our findings provide evidence that certain microbial colonization patterns among premature infants are closely associated with the pathogenesis and progression of BPD.
- by Tessa PattonIn 'sex-role reversed' species, females are socially polyandrous and compete for multiple mates, whereas males conduct the majority of parental care. To understand the extent to which physiological differences between females and males are shaped by sex roles, we examined sex differences in gene expression in […]
- by Coulter Q RalstonHigh-grade serous carcinoma (HGSC), the most lethal form of ovarian cancer, preferentially originates in the tubal epithelium (TE) of the distal uterine tube (also known as Fallopian tube or oviduct). Mouse models are widely used to study how HGSC initiates in humans; however, the extent to […]
- by Elina MäntyläCell nuclei are often used to assess cell health, but how their shapes vary in normal tissues and how they respond to mechanical forces is not well understood. Here, we describe deep invaginations of the nuclear envelope (DINEs) as common features of epithelial cell nuclei. After […]
- by Peiyu XuInfectious disease dynamics result from the complex interplay of epidemiological, ecological and evolutionary (epi-eco-evo) processes. Accurately modelling these coupled processes is crucial for understanding pathogen spread and informing public health strategies. However, existing genomic epidemiology simulators typically assume conditional independence among these processes: generating transmission trees […]
- by Hetvi S DoshiLived experience and current context are critical antecedents of emotions. However, practical methodologies for incorporating these factors into experimental emotion research remain scarce. We developed and tested an idiographic-nomothetic method to evoke a prototypically situated emotion: nostalgia. We describe the iterative qualitative and quantitative method, which […]
- by Stephanie TanisDeveloping safe, reversible, and nonhormonal male contraceptives has been hindered by the lack of defined biological windows that can be transiently interrupted without compromising long-term fertility. Here, we tested whether meiotic prophase I can serve as such a window by pharmacologically inhibiting the testis-specific chromatin reader […]
- by Emily R TetlowCONCLUSIONS: This study confirms FCGS as a disease with a quantifiable, systemic inflammatory response characterized by polyclonal hypergammaglobulinemia and mixed T helper 1/2 cytokine activation.